In vitro activity of cefepime/zidebactam and cefepime/taniborbactam against aztreonam/avibactam-resistant NDM-like-producing Escherichia coli clinical isolates
Author – Christophe Le Terrier , Patrice Nordmann, Mustafa Sadek, Laurent Poirel
Journal Name – Journal of Antimicrobial Chemotherapy
Citation – 2023 May; 78(5): 1191–1194
Successful Use of Cefepime-Zidebactam (WCK 5222) as a Salvage Therapy for the Treatment of Disseminated Extensively Drug-Resistant New Delhi Metallo-β-Lactamase-Producing Pseudomonas aeruginosa Infection in an Adult Patient with Acute T-Cell Leukemia
Author – Praveen Kumar Tirlangi, Bala Saheb Wanve, Ramakanth Reddy Dubbudu, Boorgula Sushma Yadav, L. Siva Kumar, Anand Gupta, Racha Amarthya Sree, Hari Priya Reddy Challa, P. Naveen Reddy
Journal Name – Antimicrobial Agents and Chemotherapy
Citation – Ahead of Print
In Vitro Activity of Two Cefepime-Based Novel Combinations, Cefepime/Taniborbactam and Cefepime/Zidebactam, against Carbapenemase-Expressing Enterobacterales Collected in India
Author – Bakthavatchalam YD, Elangovan D, Jaganathan SV, Subburaju N, Shankar A, Manokaran Y, J S, Devi R, Baveja S, Devi S, S J, Bhattacharya S, S M R, Yesudhason B, Shetty V, Mutreja A, Manesh A, Varghese GM, Marwick CA, Parcell BJ, Gilbert IH, Veeraraghavan B
Journal Name – Microbiology spectrum
Citation – 2023 Feb 27;11(2):e0492522
Activity of cefiderocol, imipenem/relebactam, cefepime/taniborbactam and cefepime/zidebactam against ceftolozane/tazobactam- and ceftazidime/avibactam-resistant Pseudomonas aeruginosa
Author – Cristina Lasarte-Monterrubio, Pablo Arturo Fraile-Ribot, Juan Carlos Vázquez-Ucha, Gabriel Cabot, Paula Guijarro-Sánchez, Isaac Alonso-García, Soraya Rumbo-Feal, Fátima Galán-Sánchez, Alejandro Beceiro, Jorge Arca-Suárez, Antonio Oliver, Germán Bou
Journal Name – Journal of Antimicrobial Chemotherapy
Citation – 2022, AOP, dkac241
Antimicrobial activity of cefepime/zidebactam (WCK 5222), a β-lactam/β-lactam enhancer combination, against clinical isolates of Gram-negative bacteria collected worldwide (2018–19)
Author – Helio S Sader, Rodrigo E Mendes, Leonard R Duncan, Cecilia G Carvalhaes, Mariana Castanheria
Journal Name – Journal of Antimicrobial Chemotherapy
Citation –2022, 77(10),2642-2649
In Vitro Activity of New β-Lactam–β-Lactamase Inhibitor Combinations and Comparators against Clinical Isolates of Gram-Negative Bacilli: Results from the China Antimicrobial Surveillance Network (CHINET) in 2019
Author – Yan Guo, Renru Han, Bo Jiang, Li Ding, Fengzhen Yang, Beijia Zheng, Yang Yang, Shi Wu, Dandan Yin, Demei Zhu, Fupin Hu
Journal Name – Microbiology Spectrum
Citation –2022, AOP, e0185422
Molecular Characterization of WCK 5222 (Cefepime/Zidebactam)-Resistant Mutants Developed from a Carbapenem-ResistantPseudomonas aeruginosaClinical Isolate
Author – Xiaolei Pan, Xinrui Zhao, Yuqin Song, Huan Ren, Zhenyang Tian, Qi’an Liang, Yongxin Jin, Fang Bai, Zhihui Cheng, Jie Feng, Weihui Wu
Journal Name – Microbiology Spectrum
Citation – 2022, 10(1), e02678-21
Assessment of activity and resistance mechanisms to cefepime in combination with the novel β-lactamase inhibitors zidebactam, taniborbactam and enmetazobactam against a multicenter collection of carbapenemase-producing Enterobacterales
Author – Juan Carlos Vázquez-Ucha, Cristina Lasarte-Monterrubio, Paula Guijarro-Sánchez , Marina Oviaño, Laura Álvarez-Fraga, Isaac Alonso-García, Jorge Arca-Suárez, German Bou Alejandro Beceiro
Journal Name – Antimicrobial Agents and Chemotherapy
Citation – AAC Accepted AAC.01676-21
Antimicrobial Activity of Aztreonam in Combination with Old and New -Lactamase Inhibitors against MBL and ESBL Co-Producing Gram-Negative Clinical Isolates: Possible ptions for the Treatment of Complicated Infections
Author – Gianluca Morroni, Raffaela Bressan, Simona Fioriti, Gloria D’Achille, Marina Mingoia, Oscar Cirioni, Stefano Di Bella, Aurora Piazza, Francesco Comandatore, Carola Mauri, oberta Migliavacca, Francesco Luzzaro, Luigi Principe, Cristina Lagatolla
Journal Name – Antibiotics
Citation –2021, 10(11), 1341
Activity of β-lactam plus β-lactam-enhancer combination cefepime/zidebactam against Klebsiella pneumoniae harbouring defective OmpK35/36 porins and arbapenemases
Author – Prashant Joshi, Rahul Shrivastava, Sachin Bhagwat, Mahesh Patel
Journal Name – Diagnostic Microbiology and Infectious Disease
Citation –2021, 101(2), 115481
In vitro activity of cefiderocol, cefepime/zidebactam, cefepime/enmetazobactam, omadacycline, eravacycline, and other comparative agents against carbapenem-nonsusceptible Enterobacterales: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART) in 2017–2020
Author – Yu-Lin Lee, Wen-Chien Ko, Wen-Sen Lee, Po-Liang Lu, Yen-Hsu Chen, Shu-Hsing Cheng, Min-Chi Lu, Chi-Ying Lin, Ting-Shu Wu, Muh-Yong Yen, Lih-Shinn Wang, Chang-Pan Liu, Pei-Lan Shao, Zhi-Yuan Shi, Yao-Shen Chen, Fu-Der Wang, Shu-Hui Tseng, Chao-Nan Lin, Yu-Hui Chen, Wang-Huei Sheng, Chun-Ming Lee, Hung-JenTang, Po-Ren Hsueh
Journal Name – International Journal of Antimicrobial Agents
Citation –2021, 58(3), 106377
Comment on: An update on cefepime and its future role in combination with novel β-lactamase inhibitors for MDR Enterobacterales and Pseudomonas aeruginosa
Author – Nicolau David, Bhagwat Sachin, Abdelraouf Kamilia
Journal Name – Journal of Antimicrobial Chemotherapy
Citation –2021, 76(12), 3326–3327
In vitro evolution of cefepime/zidebactam (WCK 5222) resistance in Pseudomonas aeruginosa: dynamics, mechanisms, fitness trade-off and impact on in vivo efficacy
Author – Barceló Isabel; Cabot Gabriel; Palwe Snehal; Joshi Prashant; Takalkar Swapna; Periasamy Hariharan; Cortes-Lara Sara; Zamorano Laura; Sanchez-Diener Irina; Moya Bartolome; Bhagwat Sachin; Patel Mahesh; Oliver Antonio
Journal Name – Journal of Antimicrobial Chemotherapy
Citation – JAC-2021-dkab213
Comparative in vivo activity of human-simulated plasma and epithelial lining fluid exposures of WCK 5222 (cefepime/zidebactam) against KPC- and OXA-48-like-producing Klebsiella pneumoniae in the neutropenic murine pneumonia model
Author – Maxwell J Lasko, Kamilia Abdelraouf, David P Nicolau
Journal Name – Journal of Antimicrobial Chemotherapy
Citation – 2021, 76(9) 2310–2316
Activity of cefepime/zidebactam (WCK 5222) against ‘problem’ antibiotic-resistant Gram-negative bacteria sent to a national reference laboratory
Author – Shazad Mushtaq, Paolo Garello, Anna Vickers, Neil Woodford, David M Livermore
Journal Name – Journal of Antimicrobial Chemotherapy
Citation – 2021, 76(6), 1511–1522
In vitro activity of imipenem/relebactam, meropenem/vaborbactam, ceftazidime/avibactam, cefepime/zidebactam and other novel antibiotics against imipenem-non-susceptible Gram-negative bacilli from Taiwan
Author – Shu-Chen Kuo, Yung-Chih Wang, Mei-Chen Tan, Wei-Cheng Huang, Yih-Ru Shiau, Hui-Ying Wang, Jui-Fen Lai, I-Wen Huang and Tsai-Ling Lauderdale
Journal Name – Journal of Antimicrobial Chemotherapy
Citation – 2021, dkab141, (Ahead of Print)
In vitro activity of cefepime/zidebactam (WCK 5222) against recent Gram-negative isolates collected from high resistance settings of Greek hospitals
Author – Sachin S Bhagwat, Nicholas J Legakis, Tilemachos Skalidis, Anastassios loannidis, Christos Goumenopoulos, Prashant R Joshi, Rahul Shrivasta
Journal Name – Diagnostic Microbiology and Infectious Disease
Citation – 2021, 100(3), 115327
Structural characterization of diazabicyclooctane b-Lactam "Enhancers" in complex with penicillin-binding proteins PBP2 and PBP3 of Pseudomonas aeruginosa
Author – Rajavel Malligarjunan, Kumar Vijay, Nguyen Ha, Wyatt Jacob, Marshall Steven H, Papp-Wallace Krisztina M, Deshpande Prasad, Bhavsar Satish, Yeole Ravindra, Bhagwat Sachin, Mahesh Patel, Robert A Bonomo, Focco van den Akker
Journal Name – mBio
Citation – 2021, 12(1), e03058-20
In Vitro Activity of WCK 5222 (Cefepime-Zidebactam) against Worldwide Collected Gram-Negative Bacilli Not Susceptible to Carbapenems
Author – Karlowsky James A, Hackel Meredith A, Bouchillon Samuel K, Sahm Daniel F
Journal Name – Antimicrobial Agents and Chemotherapy
Citation – 2020, 64(12), e01432-20
Activity of cefepime/zidebactam against MDR Escherichia coli isolates harbouring a novel mechanism of resistance based on four-amino-acid inserts in PBP3
Author – Sachin S Bhagwat, Periasamy Hariharan, Prashant R Joshi, Snehal R Palwe, Rahul Shrivastava, Mahesh V Patel
Journal Name – Journal of Antimicrobial Chemotherapy
Citation – 2020, 75(12), 3563-3567
Effective inhibition of PBPs by cefepime and zidebactam in the presence of VIM-1 drives potent bactericidal activity against MBL-expressing Pseudomonas aeruginosa
Author – Bartolome Moya, Sachin Bhagwat, Gabriel Cabot, German Bou, Mahesh Patel, Antonio Oliver
Journal Name – Journal of Antimicrobial Chemotherapy
Citation – 2020, 75(6), 1474-1478
Evaluation of the in vitro activity of WCK 5222 (cefepime/zidebactam) and currently available combination therapies against single- and double-carbapenemase producing Enterobacteriaceae: Expanding the zone of hope
Author – Avery Lindsay M, Mullane Elias M, Nicolau David P
Journal Name – International Journal of Antimicrobial Agents
Citation – 2020, 55(2), 105863
Comparative evaluation of the in vitro activities of WCK 5222 (cefepime/zidebactam) and combination antibiotic therapies against carbapenem-resistant Pseudomonas aeruginosa
Author – Elias M. Mullane, Lindsay M. Avery, David P. Nicolau
Journal Name – Antimicrobial Agents and Chemotherapy
Citation – 2020, 64(3), e01669-19
Efficacy of human-simulated bronchopulmonary exposures of cefepime, zidebactam and the combination (WCK 5222) against MDR Pseudomonas aeruginosa in a neutropenic murine pneumonia model
Author – James M. Kidd, Kamilia Abdelraouf, David P. Nicolau
Journal Name – Journal of Antimicrobial Chemotherapy
Citation – 2020, 75(1), 149–155
WCK 5222 (Cefepime/Zidebactam) Pharmacodynamic Target Analysis against Metallo-β-lactamase producing Enterobacteriaceae in the Neutropenic Mouse Pneumonia Model
Author – Alexander J. Lepak, Miao Zhao, David R. Andes
Journal Name – Antimicrobial Agents and Chemotherapy
Citation – 2019, 63(12), 01648-19
Activity of cefepime/zidebactam (WCK 5222) against Enterobacteriaceae, pseudomonas aeruginosa and Acinetobacter baumannii endemic to New York city medical centres
Author – Zeb Khan, Alejandro Iregui, David Landman, John Quale
Journal Name – Journal of Antimicrobial Chemotherapy
Citation – 2019, 74(10), 2938–2942
In Vivo Efficacy of WCK 5222 (Cefepime-Zidebactam) against Multidrug-Resistant Pseudomonas aeruginosa in the Neutropenic Murine Thigh Infection Model
Author – Marguerite L. Monogue, Jennifer Tabor-Rennie, Kamilia Abdelraouf, David P. Nicolau
Journal Name – Antimicrobial Agents and Chemotherapy
Citation – 2019, 63(7), e00233-19
In vitro and in vivo activity of β-lactams in combination with novel β-lactam enhancers, zidebactam and WCK 5153, against multidrug-resistant metallo-β-lactamase producing Klebsiella pneumoniae
Author – Bartolome Moya, Isabel Maria Barceló, Gabriel Cabot, Gabriel Torrens, Snehal Palwe, Prashant Joshi, Kushal Umarkar, Swapna Takalkar, Hariharan Periasamy, Sachin Bhagwat, Mahesh V. Patel, Germán Bou, and Antonio Oliver
Journal Name – Antimicrobial Agents and Chemotherapy
Citation – 2019, 63(5), e00128-19
The Novel β-Lactam Enhancer Zidebactam Augments the In Vivo Pharmacodynamic Activity of Cefepime in a Neutropenic Mouse Lung Acinetobacter baumannii Infection Model
Author – Bhagwat S. S, Periasamy H, Takalkar S. S, Palwe S. R, Khande H. N, Patel M. V
Journal Name – Antimicrobial Agents and Chemotherapy
Citation – 2019, 63(4), e02146-18
Activity of Cefepime-Zidebactam against Multidrug-Resistant (MDR) Gram-Negative Pathogens
Author – Thomson Kenneth S, Abdel Ghani Sameh, Snyder James W, Thomson Gina K, Abdel Ghani Sameh, Thomson Gina K
Journal Name – Antibiotics
Citation – 2019, 8(1), 32
Single-Center Evaluation of the Pharmacokinetics of WCK 5222 (Cefepime-Zidebactam Combination) in Subjects with Renal Impairment
Author – Richard A Preston, Grigor Mamikonyan, Stephane DeGraff, James Chiou, Christopher J Kemper, Allan Xu, Mushtaque Mastim, Ravindra Yeole, Rajesh Chavan, Anasuya Patel, H David Friedland, Ashima Bhatia
Journal Name – Antimicrobial Agents and Chemotherapy
Citation – 2019, 63(1), e01484-18
In Vivo Efficacy of Humanized WCK 5222 (Cefepime-Zidebactam) Exposures against Carbapenem-Resistant Acinetobacter baumannii in the Neutropenic Thigh Model. S.S.Almarzoky Abuhussain
Author – S.S.Almarzoky Abuhussain, Lindsay M. Avery, Kamilia Abdelraouf, David P. Nicolau
Journal Name – Antimicrobial Agents and Chemotherapy
Citation – 2019, 63(1), e01931-18
Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using β-Lactamase Inhibitors and β-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234
Author – Papp-Wallace Krisztina M, Nguyen Nhu Q, Jacobs Michael R, Bethel Christopher R, Barnes Melissa D, Kumar Vijay, Bajaksouzian, Saralee, Rudin Susan D, Rather Philip N, Bhavsar Satish
Journal Name – Journal of Medicinal Chemistry
Citation – 2018, 61(9), 4067-4086
Plasma and Intrapulmonary Concentrations of Cefepime and Zidebactam following Intravenous Administration of WCK 5222 to Healthy Adult Subjects
Author – Keith A Rodvold, Mark H Gotfried, Rakesh Chugh, Mugdha Gupta, Anasuya Patel, Rajesh Chavan, Ravindra Yeole, H David Friedland, Ashima Bhatia
Journal Name – Antimicrobial Agents and Chemotherapy
Citation – 2018, 62(8), e00682-18
Simultaneous determination of zidebactam and cefepime in dog plasma by LC–MS/MS and its application to pre‐clinical pharmacokinetic study
Author – Kiran Patil, Harshad Tambe, Vineet Zope, Rajesh Chavan, Ravindra Yeole, Mahesh V. Patel
Journal Name – Biomedical Chromatography
Citation – 2018, 32(8), e4249
Assessment of the In Vivo Efficacy of WCK 5222 (Cefepime-Zidebactam) against Carbapenem-ResistantAcinetobacter baumannii in the Neutropenic Murine Lung Infection Model
Author – Avery Lindsay M, Abdelraouf Kamilia, Nicolau David P, Nicolau David P
Journal Name – Antimicrobial Agents and Chemotherapy
Citation – 2018, 62 (11), e00948-18
WCK 5222 (Cefepime-Zidebactam) Antimicrobial Activity against Clinical Isolates of Gram-Negative Bacteria Collected Worldwide in 2015
Author – Helio S. Sader, Mariana Castanheira, Michael Huband, Ronald N. Jones, Robert K. Flamm
Journal Name – Antimicrobial Agents and Chemotherapy
Citation – 2017, 61(5), e00072-17
WCK 5222 (cefepime/zidebactam) antimicrobial activity tested against Gram-negative organisms producing clinically relevant β-lactamases
Author – Helio S Sader, Paul R Rhomberg, Robert K Flamm, Ronald N Jones, Mariana Castanheira
Journal Name – Journal of Antimicrobial Chemotherapy
Citation – 2017, 72(6), 1696-1703
Potent β-Lactam Enhancer Activity of Zidebactam and WCK 5153 against Acinetobacter baumannii, Including Carbapenemase-Producing Clinical Isolates
Author – Bartolome Moya, Isabel M. Barcelo, Sachin Bhagwat, Mahesh V. Patel, German Bou, Krisztina M. Papp-Wallace, Robert A. Bonomo Antonio Oliver
Journal Name – Antimicrobial Agents and Chemotherapy
Citation – 2017, 61(11), e01238-17
In vitro activity of cefepime/zidebactam (WCK 5222) against Gram-negative bacteria
Author – Livermore DM, Mushtaq S, Warner M, Vickers A, Woodford N,
Journal Name – Journal of Antimicrobial Chemotherapy
Citation – 2017, 72(5), 1373–1385
WCK 5107 (Zidebactam) and WCK 5153 Are Novel Inhibitors of PBP2 Showing Potent “β-Lactam Enhancer” Activity against Pseudomonas aeruginosa, Including Multidrug-Resistant Metallo-β- Lactamase-Producing High-Risk Clones
Author – Moya Bartolome, Barcelo Isabel M, Oliver Antonio, Bhagwat Sachin, Patel Mahesh, Bou German, Papp-Wallace Krisztina M, Bonomo Robert A, Papp-Wallace Krisztina M, Bonomo Robert A
Journal Name – Antimicrobial Agents and Chemotherapy
Citation – 2017, 61(6), e02529-16
