A facile one-pot, three-component protocol for, chiral synthesis of Cyanolactone as key intermediate of the Nafithromycin
Author – Furqan Diwan, Amit Pund, Prathmesh Deshpande, Rajesh Pursani, Mohammad Rafeeq, Ram Prasad Yadav, Arvind Merwade
Journal Name – Research on Chemical Intermediates
Citation – Under Review
In Vitro Activity of Nafithromycin (WCK 4873) against Chlamydia pneumoniae
Author – Stephan Kohlhoff, Margaret R. Hammerschlag
Journal Name – Antimicrobial Agents and Chemotherapy
Impact Factor – 4.45
Citation – 2021, 65(9), e00585-21
Activity of novel lactone ketolide nafithromycin against multicentric invasive and non-invasive pneumococcal isolates collected in India
Author – Balaji Veeraraghavan, Rosemol Varghese, Karnika Saigal, S Balasubramanian, P Sulochana Putli Bai, Binesh Lal Y, Ayyanraj Neeravi, Pavithra Baskar, Kavipriya Anandhan, C P Girish Kumar, Yuvraj Jayaraman, Vijaya Lakshmi Nag, Sujata Baveja, Bhavana J, Shrikrishna A Joshi, Ranganathan Iyer
Journal Name – JAC-Antimicrobial Resistance
Citation – 2021, 3(2), dlab066
Preclinical safety evaluation of nafithromycin (WCK 4873) with emphasis on liver safety in rat and dog
Author – Nandanwar, Manohar; Chavan, Rajesh; Kansagara, Atul; Patel, Muftedar Ahmed; Patel, Anasuya; Yeole, Ravindra; Patel, Mahesh
Journal Name – Regulatory Toxicology and Pharmacology
Impact Factor – 2.89
Citation – 2021, 122, 104889
Assessment of the in vitro cytochrome P450 (CYP) inhibition potential of Nafithromycin, a next generation lactone ketolide antibiotic
Author – Rajesh P. Chavan , Vineet S. Zope , Nilesh N. Chavan , Kiran Patil , Ravindra D. Yeole , Sachin B. Bhagwat & Mahesh V. Patel
Journal Name – Xenobiotica
Impact Factor – 1.902
Citation – 2021, 51(3), 251-261
Pre-treatment of nafithromycin attenuates inflammatory response in murine lipopolysaccharide induced acute lung injury
Author – Trivedi Jinal, Shaikh Javeed, Chavan Nilesh, Thorve Deepak, Chaudhary Bhushan, Karade Avinash, Gupta Sangita, Patel Anasuya, Bhagwat Sachin
Journal Name – Journal of Cytokine
Impact Factor – 2.952
Citation – 2020, 129, 155049
Safety, Tolerability, and Pharmacokinetics of Oral Nafithromycin (WCK 4873) after Single or Multiple Doses and Effects of Food on Single-Dose Bioavailability in Healthy Adult Subjects
Author – Piotr Iwanowski, Ashima Bhatia, Mugdha Gupta, Anasuya Patel, Rajesh Chavan, Ravindra Yeole, David Friedland
Journal Name – Antimicrobial Agents and Chemotherapy
Impact Factor – 4.921
Citation – 2019, 63(12), e01253-19
Identification and Quantification of Related Impurities of a Novel Ketolide Antibiotic Nafithromycin
Author – V. Ahirrao, V. Rane, K. Patil, Rajiv A. Jadhav, V. Shinde, V. V. Deshmukh, Sanjay K. Dabhade, R. Kale, S. K. Gupta, R. D. Yeole
Journal Name – Chromatographia
Impact Factor – 1.596
Citation – 2019, 82(7),1059–1068
Enantiomeric Separation and Thermodynamic investigation of (R)-5-[1-(4-Nitrobenzylsulfonyloxy)-ethyl]-5-(pyridine-2-yl)- [1,3,4]-thiadiazole, a Key Intermediate of Nafithromycin
Author – Rane Vipul P, Ahirrao Vinod K, Patil Kiran R, Jadhav Rajiv A, Ingle Rahul G, More Kiran B, Yeole Ravindra D
Journal Name – Analytical Chemistry Letters
Impact Factor – 1.727
Citation – 2019, 9(5), 625-633
Simultaneous determination of novel ketolide antibiotic nafithromycin and its major metabolite in human plasma using liquid chromatography tandem mass spectrometry
Author – Patil Kiran R, Yeole Ravindra D, de Zwart Marcel, Pruim Peter
Journal Name – Bioanalysis
Impact Factor – 2.371
Citation – 2019, 11(19), 1767-1776
In Vitro Activity of the Novel Lactone Ketolide Nafithromycin (WCK 4873) When Tested against Contemporary Clinical Bacteria from a Global Surveillance Program
Author – R. K. Flamm, P. R. Rhomberg, H. S. Sader
Journal Name – Antimicrobial Agents and Chemotherapy
Impact Factor – 4.548
Citation – 2017, 61(12), e01230-17
Determination of Disk Diffusion and MIC Quality Control Ranges for Nafithromycin (WCK 4873), a New Lactone-Ketolide
Author – Hackel Meredith A, Karlowsky James A, Dressel Dana, Daniel F
Journal Name – Journal of Clinical Microbiology
Impact Factor – 4.054
Citation – 2017, 55(10), 3021-3027
Comparison of Plasma and Intrapulmonary Concentrations of Nafithromycin (WCK 4873) in Healthy Adult Subjects
Author – Rodvold, Keith A, Gotfried Mark H, Chugh Rakesh, Gupta Mugdha, David Friedland H, Bhatia Ashima
Journal Name – Antimicrobial Agents and Chemotherapy
Impact Factor – 4.548
Citation – 2017, 61(9), e01096-17
